Managed information gathering and fusion for transient transport problems

This paper deals with vehicular traffic management by communication technologies from Traffic Control Center point of view in road networks. The global goal is to manage the urban traffic by road traffic operations, controlling and interventional possibilities in order to minimize the traffic delays and stops and to improve traffic safety on the roads. This paper focuses on transient transport, when the controlling management is crucial. The aim was to detect the beginning time of the transient traffic on the roads, to gather the most appropriate data and to get reliable information for interventional suggestions. More reliable information can be created by information fusion, several fusion techniques are expounded in this paper. A half-automatic solution with Decision Support System has been developed to help with engineers in suggestions of interventions based on real time traffic data. The information fusion has benefits for Decision Support System: the complementary sensors may fill the gaps of one another, the system is able to detect the changing of the percentage of different vehicle types in traffic. An example of detection and interventional suggestion about transient traffic on transport networks of a little town is presented at the end of the paper. The novelty of this paper is the gathering of information - triggered by the state changing from stationer to transient - from ad hoc channels and combining them with information from developed regular channels. --information gathering,information fusion,Kalman filter,transient traffic,Decision Support System

A politikai párt diszkurzív valósága: a Fidesz-MPSZ vizsgálata = Discursive Approach to the Political Party: Research of Fidesz-MPSZ

Az empirikus kutatás FIDESZ - Magyar Polgári Párt, illetve Magyar Polgári Szövetség sajátosságait vizsgálta, különös tekintettel az 1998 utáni időszakra. A kutatás három nagyobb tématerületet fogott át A Reflexió a Fidesz diskurzusát olyan politikai nyelvnek mutatta, amely egy-egy helyzetre és kihívásra adott válaszként fogható fel, ahol is a válasz mélyen beépül a párt önképébe és valóságfelfogásába. A kutatás egy mérsékelt politikai jelenlét, választási vereség és szervezeti elégtelenség problémájának nyelvi megoldását elemezte. A Konstrukció témakör a nyelvi konstrukciót helyezte a vizsgálat középpontjában, azaz a Fidesz diskurzusát általános nyelvi valóságteremtésnek fogta fel. A kutatások azt a figyelemre méltó tényt vizsgálták meg, hogy a Fidesz diskurzusába miként váltak dominánssá nem-politikai kifejezések. A harmadik, a Kontextus azt elemezte, hogy a politikai élet más szereplői hogyan beszéltek a Fideszről, és ezzel persze önmagukról. Konkrétan azt nézték meg, hogy milyen Fidesz képet prezentált egy politikai hetilap, egy folyóirat és egy könyv, illetve, hogy maga politikatudomány hogyan vett részt a ?Fidesz-teremtésben?. A kutatás két fontos tanulságra is ráirányította a figyelmet. Az egyik, hogy a Fidesz a politika nyelvét és gondolkodását az elemzett időszakban morális és szakrális irányba mozdította el. A másik feltárt vonás, hogy a Fidesz újrakonstruálta saját helyét és szerepét, ezzel együtt a magyar politikai életet több dimenzióját is. | This empirical research studied the characteristics of FIDESZ ? Magyar Polgári Párt, with special emphasis on the period after 1988. The research included three main topics. Reflection interpreted the discourse of Fidesz as a political language formed in reaction to particular situations and challenges, where such reactions were deeply embedded in the party?s self-image and interpretation of reality. The research analysed the linguistic solutions to the problems of moderate political presence, losing the elections and organisational deficiencies. The topic of Construction focused on linguistic construction, that is, it interpreted the discourse of Fidesz as a general linguistic creation of reality. The studies analysed the remarkable process in which non-political expressions became dominant in the discourse of Fidesz. Context, in contrast to the previous two topics, analysed how other participants of politics talked about Fidesz and, through this, about themselves. The research studied in particular the kind of Fidesz image presented in a political weekly, a journal and a book, and also how political science itself participated in the ?creation of Fidesz.? Our results highlighted two important conclusions. One is that in the given period Fidesz motioned the language and thinking of politics into a moral and sacral direction. The other conclusion is that Fidesz reconstructed its own position and role together with several dimensions of Hungarian political life

PRMT1 and PRMT8 regulate retinoic acid-dependent neuronal differentiation with implications to neuropathology.

Retinoids are morphogens and have been implicated in cell fate commitment of embryonic stem cells (ESCs) to neurons. Their effects are mediated by RAR and RXR nuclear receptors. However, transcriptional cofactors required for cell and gene-specific retinoid signaling are not known. Here we show that protein arginine methyl transferase (PRMT) 1 and 8 have key roles in determining retinoid regulated gene expression and cellular specification in a multistage neuronal differentiation model of murine ESCs. PRMT1 acts as a selective modulator, providing the cells with a mechanism to reduce the potency of retinoid signals on regulatory "hotspots." PRMT8 is a retinoid receptor target gene itself and acts as a cell type specific transcriptional coactivator of retinoid signaling at later stages of differentiation. Lack of either of them leads to reduced nuclear arginine methylation, dysregulated neuronal gene expression, and altered neuronal activity. Importantly, depletion of PRMT8 results in altered expression of a distinct set of genes, including markers of gliomagenesis. PRMT8 is almost entirely absent in human glioblastoma tissues. We propose that PRMT1 and PRMT8 serve as a rheostat of retinoid signaling to determine neuronal cell specification in a context-dependent manner and might also be relevant in the development of human brain malignancy

Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain

Transcriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential in the development and maintenance of prolonged pain. Epigenetic mechanisms including post-translational mo difications in histones are pivotal in regulating transcription. Here, we report th at phosphorylation of serine 10 (S10) in histone 3 (H3) specifically occurs in a group of rat SSDHN following the activation of nociceptive primary sensory neurons by burn injury, capsaicin application or sustained electrical activation of nociceptive primary sensory nerve fibres. In contrast, brief thermal or mechanical nociceptive stimuli, which fail to induce tissue injury or inflammation, do not produce the same effect. Blocking N-methyl-D-aspartate receptors or activation of extracellular signa l-regulated kinases 1 and 2, or blocking or deleting the mitogen- and stress-activated kinases 1 and 2 (MSK1/2), which phosphorylate S10 in H3, inhibit up-regulation in phosphorylated S10 in H3 ( p - S10H3) as well as fos transcription, a down-stream effect of p -S10H3. Deleting MSK1/2 also inhibits the development of carrageenan-induced inflammatory heat hyperalgesia in mice. We propose that p -S10H3 is a novel marker for nociceptive processing in SSDHN with high relevance to transcriptional changes and the development of prolonged pain

The a-theoretical core of political realism

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Shakespeare between Machiavelli and Hobbes : Dead Body Politics

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Alison McQueen. Political Realism in Apocalyptic Times . New York: Cambridge University Press, 2017. Pp. xiii+235. $105.00 (cloth).

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Role of Altered Expression of miR-146a, miR-155, and miR-122 in Pediatric Patients with Inflammatory Bowel Disease

BACKGROUND: Evidence suggests the central role of tumor necrosis factor (TNF)-alpha in the pathomechanism of inflammatory bowel disease (IBD); however, its effect on epigenetic factors, including small non-coding microRNAs (miRs), is less known. Our present aim was the comparative investigation of the expression of TNF-alpha and immune response-related miRs in children with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Fresh-frozen (FF) and formalin-fixed, paraffin-embedded (FFPE) biopsies were used to analyze the expression of miR-146a, -155, -122, and TNF-alpha by real-time reverse transcription polymerase chain reaction in macroscopically inflamed (CD: 12 FFPE and 24 FF; UC: 10 FF) and intact (CD: 12 FFPE; 14 FF) colonic biopsies of children with IBD and controls (16 FFPE; 23 FF). The expression of miR-146a, -155, and -122 was also determined in TNF-alpha-treated HT-29 colonic epithelial cells. RESULTS: Increased expression of TNF-alpha was observed in the colonic mucosa of children with CD and UC in comparison with controls. Expression of miR-146a and -155 was higher in the inflamed mucosa of children with CD and UC than in the intact mucosa. Expression of miR-122 elevated in the macroscopically intact colonic regions of CD compared with controls and patients with UC. In HT-29 cells, TNF-alpha treatment increased the expression of miR-146a and -155, but not that of miR-122. CONCLUSIONS: Our results showed altered expression of miR-146a, -155, and -122 in the colonic mucosa of children with IBD and in TNF-alpha-treated colonic epithelial cells. Our data suggest the TNF-alpha-related involvement of these miRs in the pathogenesis of IBD